Figure 1From: Mild forms of hypophosphatasia mostly result from dominant negative effect of severe alleles or from compound heterozygosity for severe and moderate alleles Location of the dominant mutations on the three-dimensional model of TNAP. The model is based on the crystal structure of the placental isoform [23]. The two monomers are shown in magenta and yellow. The active site is shown in green and the residues affected by dominant mutations in cyan.Back to article page