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Table 4 Concordance between asthma analyses and the current study

From: PLAURpolymorphisms and lung function in UK smokers

SNP

Allele

*Asthma Susceptibility

Decline in FEV1 in asthma

*Serum PLAUR

COPD Susceptibility

COPD Severity

(GOLD 1/4)

Baseline FEV1

Baseline FEV1/FVC

rs4803648

T

Risk

Accelerated

-

-

-

-

-

rs4802189

C

Risk

Accelerated

-

-

-

-

-

rs4251953

A

-

Accelerated

-

-

-

-

-

rs4251938

G

Risk

-

-

-

-

-

-

rs4251923

A

-

-

-

-

-

-

-

rs4760

C

-

Slowed

-

-

-

-

-

rs2302524

C

Risk

Accelerated

-

-

-

Decreased

-

rs4251864

C

-

-

-

-

-

-

-

rs2239372

A

Risk

-

Increased

-

-

-

-

rs2283628

C

-

-

-

-

-

Increased

-

rs4251846

T

-

-

-

-

-

-

-

rs2239374

T

-

-

-

-

-

-

-

rs2286960

T

-

Slowed

-

-

-

-

-

rs4251805

A

-

-

-

-

-

-

-

rs344781

C

-

NA

-

-

-

-

-

rs2356338

T

Risk

Accelerated

Increased

-

-

-

-

rs344780

T

-

-

-

-

-

-

-

rs344779

T

-

-

-

-

-

-

Increased

rs8113334

C

--

-

-

-

-

-

-

rs4493171

T

Protection

-

Decreased

-

-

-

-

rs7259340

A

-

-

-

-

-

-

-

rs11668247

T

-

-

-

-

Protection

-

Increased

rs346043

C

Risk

Accelerated

Increased

-

-

-

-

rs740587

C

-

-

-

Protection

-

-

Increased

rs346054

G

-

-

-

-

-

-

-

  1. *Significant Family Based Association Test (FBAT) results from our previous study.[3] using three asthma family cohorts from Nottingham, Southampton and The Netherlands (n = 587 families). The asthma patients that were probands of the Dutch asthma families (n = 200) were longitudinally followed in the Netherlands for approximately 30 years (1965-1995). FEV1 decline over time was modelled. FEV1 forced expiratory volume in one second; FVC forced vital capacity. NA = Not available.
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BMC Medical Genetics

ISSN: 1471-2350

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