Figure 1From: PLAURpolymorphisms and lung function in UK smokers Schematic representation of the PLAUR gene and haplotype block structure of PLAUR SNPs in smokers. (A) Schematic representation of the PLAUR gene on chromosome 19 illustrating the position of SNPs 1-13 (see Table 2). SNPs 14-25 located in the promoter region/5'region are omitted for clarity. The PLAUR gene is displayed in the reverse orientation to that observed on chromosome 19 (~40 kb). Exons are depicted as open boxes except for alternatively spliced exon 7 (VIIB, grey, see [34]). (B) Haplotype block structure of all 25 SNPs on Chromosome 19 in smokers (n = 992). The colour of shading represents R2 (a measure of LD) and numerical values are given (generated using Haploview software [13]). Haplotype blocks were defined using confidence intervals for strong LD D' 0.7-0.98.Back to article page