Figure 1

Family trees of the probands carrying the S127L variant. This variant was found in three unrelated subjects from three different obesity Services. A show the family tree of subject 1 (see Table 1). The figure shows that all the carriers but the subject I 2 (grandmother) were obese. B and C show the family trees of patients 2 and 3, respectively (see Table 1). The half black square indicates males heterozygotes for the mutation, the half black circle indicates the females heterozygotes for the mutation.